There are substances working synergistically for glutathione production.
Defination of cofactor: A substance, such as a metallic ion or coenzyme, that must be associated with an enzyme for the enzyme to function eg., Selenium, Vitamin C, B6, B12, folic acid, vitamin E, and other micronutrients, are included in the substances called co-factors.
Vitamin E: Like selenium Vitamin E is an antioxidant, a detoxifier, and helps to keep glutathione in its reduced (non-oxidized) state. Dosages up to 400IU are recommended.
Side effects: Excessive intake can be toxic creating gastrointestinal and neurological side-effects.
Silymarin (Milk Thistle): The milk thistle plant, (Silybum marianum, silymarin) has a long history in the treatment of liver problems. It clearly prevents the oxidation of fats and maintains glutathione levels, but possible toxic reactions include gas, cramps and diarrhoea. Liver disease should never be treated without the supervision of a health professional.
Selenium: The mineral selenium also produces subtle elevations in glutathione by becoming integrated into the enzyme glutathione peroxidase.
Side effects of over doses occur around 400 mcg/day and include hair loss, numbness or tingling in the fingers or toes, and white spots on fingernails and toenails. Selenium overdose leads to an indirect glutathione side effect.
Glutamine: Whether taken orally or intravenously, glutamine supplements raise glutathione concentrations.
Side effects: Completely healthy individuals shouldn't require supplemental glutamine and it can lead to side effects such as gastrointestinal upset. Older people as well as kidney and liver patients should be cautious. Any serious use of this supplement must be monitored by a health professional.
